Inhibitory Effect of Tomato Juice on Rat Urinary Bladder Carcinogenesis After N-Butyl-N-(4-hydroxybutyl)Nitrosamine Initiation
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چکیده
منابع مشابه
Effects of promoters on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced urinary bladder carcinogenesis in the rat.
It has been shown that the occurrence of the preneoplastic lesion, papillary or nodular hyperplasia (PN hyperplasia) in rat urinary bladder induced by carcinogens is correlated with that of cancer. Therefore, the promoting effects of chemicals in two-stage bladder carcinogenesis were judged by measuring their ability to induce PN hyperplasia in rats. Male rats were given N-butyl-N-(4-hydroxybut...
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The effects of ethyl tertiary-butyl ether (ETBE) on two-stage urinary bladder carcinogenesis in male F344 rats initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) were investigated at various dose levels with regard to possible promoting activity. Groups of 30 rats were given drinking water containing 500 ppm BBN, as an initiator, for 4 weeks and starting one week thereafter received ETB...
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Overexpression of ornithine decarboxylase (ODC) has been shown to be characteristic of tumor development and progression in humans and experimental animals. Therefore, we have examined the effects of 1, 3-diaminopropane dihydrochloride (DAP), a potent inhibitor of ODC, on rat two-stage urinary bladder carcinogenesis initiated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN). In experiment 1 (36...
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The effect of 13-cis-retinoic acid on the induction of urinary bladder carcinoma by N-butyl-N-(4-hydroxybutyl)nitrosamine (OH-BBN) was studied in male C57BL/6 mice. Animals received a total dose of either 90 or 140 mg of OH-BBN via gastric intubations of 7.5 or 10.0 mg of OH-BBN 2 times each week for 6 or 7 weeks, respectively. Seven days after the last OH-BBN intubation, animals were fed labor...
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The potential enhancing effects of the regeneration response of the urothelium following ulcération of the bladder mucosa on A/-butyl-/V-(4-hydroxybutyl)nitrosamine Carcinogenesis were examined in male Fischer rats. The carcinogen was adminis tered in the drinking water at a concentration of 0.05% for 2 weeks. Ulcérationwas performed by a freezing technique 24 hr before the administration or ...
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ژورنال
عنوان ژورنال: The Journal of Urology
سال: 1998
ISSN: 0022-5347
DOI: 10.1097/00005392-199811000-00088